Evaluation of the effect of exposure to endocrine disruptors on the area and number of adipocytes per unit of area in abdominal tissue in mice
Date
2021-05-04
Authors
Cuartas Quo, Diana Cristina
Agudelo Ortiz, Alejandra
Gómez Mercado, Carlos Alberto
Mejía Sandoval, Gregory
Arias Gutiérrez, María Patricia
Moreno, Ricardo D.
Patiño García, Daniel
Orellana, Renan
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Abstract
Obesogens are endocrine disruptors due to their ability to interrupt hormone systems and cause adverse developmental, reproductive, neurological, and immunological effects in mammals, altering normal lipid metabolism and adipogenesis. The study used an in vivo mice models to evaluate the effects of in utero and postnatal exposure to obesogens on adipose cellularity and adipocyte area in offspring. The experimental groups included low & high dosages of obesogens, a mixed dosage and a control. The number and area of adipocytes was then evaluated. Results demonstrated a significant difference in cell number and area even at the lowest dosages, indicating that even exposure to low quantities of obesogens cause measurable changes in adipose tissue. In future studies, it is important to continue research into the quantification of their effects, relating specific dosages of obesogens to their consequences on adipose tissue.
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Keywords
BPA, DEHP, Endocrine disrupting chemicals (EDC), Obesogens, Prenatal exposure