Sensitivity of oral microorganisms to blood-derived products and their relationship with sex and age - A pilot study
Date
2025-12-15
Journal Title
Journal ISSN
Volume Title
Publisher
Universidad CES
Referencia bibliográfica
Abstract
Background: Autologous blood derivatives have gained relevance in regenerative dentistry due to their potential to modulate inflammation and promote tissue repair; however, their influence on oral microbial growth remains insufficiently characterized. Material and Methods: A sample of 10 participants of varied ages and sexes was included. Microbial strains were cultured and exposed to blood derivatives obtained through standard centrifugation procedures. Microbial growth kinetics were recorded via spectrophotometry at 620 nm for 14 hours and analyzed using LOESS non-parametric models, ANOVA, Kruskal–Wallis, and Pearson correlation. Results: SA, SI, and PRP displayed inhibitory effects on microbial growth, with PRP demonstrating the most notable bacteriostatic activity compared with the control, reducing microbial viability prior to the exponential phase. PPP showed the weakest inhibitory response. No statistically significant associations were found between sex or age and the evaluated variables. Conclusions: SI, SA, and PRP exhibited the greatest antimicrobial potential against the tested oral microorganisms, suggesting their possible use as adjuvants in regenerative therapies and in preventing odontogenic infections. This pilot study provides preliminary evidence regarding the influence of blood derivatives and individual biological factors on microbial response, highlighting the need for future studies with larger samples.
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Keywords
Bacterial growth, Immunity, Complement, Platelet-rich plasma, Bactericidal activity of blood