Bioinformatic identification of the CRISPR-Cas system within the genus Leptospira
Date
2025-06-10
Journal Title
Journal ISSN
Volume Title
Publisher
Universidad CES
Abstract
Background/Objectives: In this study, the objective is to
identify, through a bioinformatics analysis of their genomes, the type
of CRISPR-Cas system and its component elements in the 69 reference
Leptospira species Methods: Three online bioinformatic tools were used
for this: CRISPRcasFinder, RAST, and PHASTEST. Results: The results
show that 20 Leptospira species contain phage sequences, primarily
within clades P1 and P2. Most of the identified CRISPR-Cas systems
belong to Class I, mainly subtype I-E. Conclusions: This study
concludes that due to the presence of cas genes, spacers, and their
diversity support the active functionality of the CRISPR-Cas system in
at least 20 Leptospira species.
Description
Keywords
CRISPR-CAS, Leptospira, Leptospirosis
Citation
IEEE