Abstract

El Clopidogrel inhibe la agregación plaquetaria inducida por la ADP y bloquea de forma selectiva e irreversible su receptor en la superficie plaquetaria. El clopidogrel interfiere con las vias de señalización intraplaquetaria que conduce a la activacion de la GP IIb/IIIa. Su metabolismo es hepatico, sin embargo, su eliminacion es urinaria. | ABSTRACT: Clopidogrel inhibits platelet aggregation induced by ADP and blocks selectively and irreversibly its receptor on the platelet surface. Clopidogrel interferes with intraplatelet signaling pathways leading to activation of GP IIb / IIIa. Its metabolism is hepatic, however, its elimination is urinary.